Talk of Florian Engert at the CRG on 07/09/12 at 12:00 (PRBB, Marie Curie room)

 PRBB-CRG Session organized by PhD Students

07/09/2012 at 12:00h, Marie Curie room (ground floor)


Department of Molecular and Cellular Biology, Harvard University, Cambridge (MA) US

"Sensory processing and motor control in larval zebrafish"

Host: Andreas Braun (CRG)


A fundamental question in neuroscience is how neural circuits generate behavior and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging throughout the brain of larval zebrafish while the paralyzed animals interact fictively with a virtual environment and rapidly adapt their motor output to changes in visual feedback. We describe the neural dynamics that occur during adaptive locomotion throughout the brain of the fish, and provide an anatomical map of their locations. A subset of these signals occurred during behavioral adjustments and are attractive candidates for the functional elements that drive motor learning. This work enables us to propose a specific model of a neural circuit that detects mismatches between expected and actual feed-back and adjusts the sensory motor transformation accordingly.

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