Puig Lab – Neuromodulation of neural networks and circuits

The Puig laboratory studies the neural substrates of executive function via in vivo electrophysiology in awake behaving mice combined with pharmacology. More specifically, the group records single-unit and neural network activity (neural oscillations) intracerebrally in mice performing a battery of cognitive tasks (operant and nonoperant). The group´s main research lines focus on 1) the study of the alterations in synchronized neural activity of dysfunctional neural networks present in psychiatric disorders (schizophrenia), neurodegenerative disorders (Parkinson), and genetic disorders that result in intellectual disability (Down syndrome), 2) the study of how conventional and newly developed pharmacological treatments normalize this aberrant activity (e.g. first vs. second generation antipsychotics), and 3) the role played by neuromodulators (serotonin, dopamine) in the regulation of neural network activity during cognition.

             

Contact Data
Adress: 
Doctor Aiguader 88 | 08003 Barcelona
Phone: 
+34 93 3160482
email: 
mpuig3@imim.es
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